George McDonald Church (1954 – 2023->) is an American synthetic biologist. I’m pathologically calm.

George Church responded to Steven Colbert‘s (0:44/1:46) provocative questions about resurrecting mammoths and living forever by comically looking at the ceiling.
Preventing the ongoing extinction of elephants, rhinoceroses, and other threatened species is critically important.
George Church’s sentiment on preventing the extinction of threatened species like elephants and rhinoceroses highlights a profound appreciation for the intricate web of life and the importance of biodiversity. By emphasizing the urgency of conservation, Church underscores that these magnificent creatures not only hold intrinsic value but also play pivotal roles in their ecosystems, contributing to ecological balance, evolutionary dynamism, and the overall health of the environment. Their loss would signify not just the disappearance of individual species but also a disruption in the natural order, potentially leading to unforeseen negative consequences for the planet and humanity. Thus, safeguarding them is not merely an act of compassion but also an essential step towards preserving the harmony and resilience of Earth’s ecosystems.
The goal of reanimation research is not to make perfect living copies of extinct organisms, nor is it meant to be a one-off stunt in a laboratory or zoo. Reanimation is about leveraging the best of ancient and synthetic DNA.
George Church’s perspective on reanimation research dives deep into the potential harmony between ancient genetics and modern biotechnology. Instead of merely replicating past life forms or indulging in temporary scientific showmanship, reanimation aims to meld the essence of ancient organisms with advancements in synthetic DNA. This convergence promises novel insights into evolution and biology and paves the way for innovative solutions to contemporary challenges. By intertwining the wisdom of the ancient world with today’s technological prowess, reanimation embodies the potential for groundbreaking discoveries that transcend time, merging the past and present to envision and shape a better future.
My laboratory and my obsession is about safety and building/engineering safety. It’s not just saying we want the world to be safer; we must create technology.
George Church’s emphasis on proactive safety in scientific and technological pursuits underscores a forward-thinking and responsible approach to innovation. Rather than merely articulating the desire for a safer world, Church advocates for the tangible creation and implementation of technology that inherently prioritizes safety. This philosophy acknowledges the profound impact and potential risks of rapidly advancing technologies, emphasizing the need for rigorous safeguards. By intertwining safety with the fabric of innovation, Church’s vision ensures that progress is not only remarkable but also conscientiously directed towards the betterment and protection of society.
The goal of getting your genome done is not to tell you what you will die from but to learn how to take action to prevent disease.
George Church’s insight into genomic research reframes the perception of personal genetic information from a deterministic fate to a proactive tool for health management. Instead of viewing our genome as a fixed script of our future ailments, Church emphasizes its potential as a roadmap to navigate and mitigate health risks. By understanding one’s genetic predispositions, individuals can make informed decisions, adopt tailored preventative measures, and collaborate with healthcare professionals to optimize their well-being. This proactive approach underscores knowledge empowerment, turning potential vulnerabilities into opportunities for enhanced health and longevity.
Many revolutions look irrelevant just before they change everything swiftly.
George Church’s observation of the nature of revolutionary ideas encapsulates innovation’s unpredictability and transformative power. Often, groundbreaking concepts or technologies may appear marginal or inconsequential on the cusp of their emergence, only to rapidly shift paradigms and reshape societal structures. Church’s insight cautions against underestimating or dismissing the potential of seemingly peripheral ideas, as history has shown that these very concepts can swiftly redefine the status quo. This wisdom underscores the importance of open-mindedness, adaptability, and recognizing that profound change often arises from unexpected quarters.
Successful innovators keep juggling ideas in the air, in the back of their minds, to inspire and enable new recombinations.
George Church’s reflection on the mindset of successful innovators encapsulates the dynamic interplay of creativity and persistence. By suggesting that innovators constantly “juggle” ideas, he emphasizes the continuous engagement with diverse concepts, allowing them to collide, intertwine, and evolve. This mental agility fosters an environment where breakthroughs often arise from unexpected combinations or iterations of pre-existing thoughts. Church’s perspective highlights that innovation is not just about the eureka moments but also about nurturing a mental landscape where ideas are free to mingle, mutate, and eventually coalesce into something transformative.
The best way to predict the future is to change it.
George Church’s assertion that “the best way to predict the future is to change it” encapsulates the proactive and empowered stance one can take in shaping one’s destiny. Rather than passively forecasting or reacting to external events, Church emphasizes the agency and influence individuals and communities possess in actively molding the trajectory of the future. This perspective underscores the intertwined relationship between foresight and action, suggesting that by understanding potential outcomes and taking deliberate steps, one can anticipate and sculpt the path forward, creating a future aligned with one’s vision and values.
Very often, as I wander through life, I’ll get that old feeling that I’ve returned from the future, and I’m living in the past. And it’s a really horrible feeling.
George Church’s reflection on feeling as though he’s “returned from the future” vividly conveys the dissonance innovators and visionaries often experience when their forward-looking ideas clash with the present’s realities. This sentiment encapsulates the challenges of being ahead of one’s time, where profound insights or revolutionary concepts are not yet recognized or embraced by the broader society. Church’s description underscores the potential isolation and frustration felt by those who glimpse possibilities beyond current paradigms, reminding us of the importance of nurturing and valuing pioneering thinkers, even when their visions seem misaligned with the current zeitgeist.
The rewards for biotechnology are tremendous – to solve disease, eliminate poverty, and age gracefully. It sounds so much more profound than Facebook.
In George Church’s comparison between the profound potential of biotechnology and the digital realm represented by platforms like Facebook, he underscores scientific advancements’ tangible, life-altering impact. While social media platforms offer connectivity and entertainment, biotechnology dives into the core of human existence, promising solutions to long-standing challenges like disease, poverty, and aging. Church’s insight accentuates biotech’s profound, transformative potential, reminding us that while technological tools and platforms might captivate our attention, the foundational work in fields like biotechnology holds the promise to significantly elevate the quality of human life.
Every disease with us is caused by DNA, and every disease can be fixed by DNA.
George Church’s assertion about DNA’s role in disease highlights the foundational significance of genetics in human health and potential therapeutics. By identifying DNA as the root of all ailments and their possible solution, Church emphasizes the profound power embedded within our genetic code. This dual perspective illuminates the idea that while genetic mutations or malfunctions can lead to diseases, with advanced understanding and manipulation of DNA, we possess the potential to rectify these issues at their source. Church’s insight speaks to the transformative promise of genetic research and therapies, positioning DNA as the keystone for understanding and combatting human diseases.
You can’t just hoard your ideas inside the ivory tower. You have to get them out into the world.
George Church’s perspective on disseminating ideas emphasizes the imperative of bridging academic or specialized realms with the broader society. The “ivory tower” metaphor, often associated with isolated academic pursuits, is juxtaposed against the real-world application and impact of knowledge. Church’s statement underscores that ideas must be shared, tested, and applied outside insular environments to achieve their transformative potential. By advocating for the externalization of insights and discoveries, Church champions the belief that true innovation arises from the intersection of theory and practice, urging experts to not just conceive but also to catalyze change in the broader world.
It is impossible to outlaw entire technologies.
George Church’s assertion that “it is impossible to outlaw entire technologies” reflects a recognition of the unstoppable tide of technological advancement and its pervasive influence on society. This insight acknowledges that once a technology is introduced or conceptualized, its widespread suppression becomes impractical due to the globalized nature of information and the innate human drive for progress. Instead of attempting to halt technological evolution, the focus should shift to responsible development, ethical implementation, and informed regulation. Church’s perspective underscores the necessity of embracing change while ensuring that technology serves humanity in beneficial and equitable ways.
The main goal is to increase diversity. The one thing that is bad for society is low diversity. This is true for culture or evolution, species, and whole societies. If you become a monoculture, you are at great risk of perishing.
George Church’s emphasis on the paramount importance of diversity underscores its role as a bedrock principle in sustaining and enriching life and society. Whether viewed through the lens of culture, evolution, or ecosystems, diversity is a buffer against threats and a driver for innovation and adaptability. Whether biological or societal, monocultures expose systems to vulnerabilities where a single threat can lead to collapse. In contrast, diverse systems can absorb shocks, offer varied responses, and engender resilience. Church’s insight serves as a potent reminder that, in fostering diversity, we not only enrich the present but also ensure the robustness and vibrancy of the future.
I am very much in awe of nature. In fact, I think to some extent, “awe” was a word that was almost invented for scientists.
George Church’s reflection on the profound sense of “awe” experienced by scientists towards nature encapsulates the deep reverence and curiosity that drives scientific inquiry. By suggesting that “awe” is tailor-made for scientists, Church emphasizes the profound connection between the quest for knowledge and the overwhelming appreciation for the universe’s intricacies. This sentiment is a testament to the idea that science, at its core, is not just a pursuit of answers but also a continuous journey of marveling at the mysteries and wonders of existence, where understanding and admiration coalesce in the quest for discovery.
The goal is to be able to change the genome as radically as our understanding permits.
George Church’s statement on the aspiration to modify the genome as profoundly as our understanding allows encapsulates the confluence of knowledge and capability in the realm of genetic engineering. By linking the extent of change to the depth of understanding, Church underscores a balanced approach: technological prowess should be tempered by comprehensive knowledge. The sentiment suggests that as we gain deeper insights into the intricate workings of the genome, we simultaneously unlock greater potential for beneficial interventions. Yet, this very understanding should guide the ethical and responsible application of such capabilities, ensuring that progress is anchored in wisdom and foresight.
If we go into space, we need enhancements that handle radiation and osteoporosis… or else we’re dead.
George Church’s insight regarding space exploration underscores the immense physiological challenges posed by extraterrestrial environments and the necessity of proactive biological adaptations to ensure human survival. Highlighting threats like radiation and osteoporosis, Church emphasizes that traditional protective measures, like spacecraft shielding, may not be enough. Instead, he points to the potential of genetic or biomedical enhancements as a means to bolster the human body’s resilience in space. This perspective reflects a forward-thinking approach to space exploration, suggesting that the key to thriving beyond Earth may lie in optimizing our own biology, not just our external technologies.
We have a love affair with the idea of the ‘natural,’ even though we, as a species, are about as unnatural as you can imagine.
George Church’s reflection on humanity’s perception of the “natural” challenges the often-held dichotomy between human-made and nature-derived. By highlighting humanity’s unique capacity for profound environmental and technological impact, he suggests that our very existence and actions blur the lines of what is conventionally deemed “natural.” This observation prompts a reevaluation of how we define and relate to nature, emphasizing that humans, with our transformative capacities, are both a part of and an exception to the natural world. Church’s idea underscores the intricate interplay between humanity’s evolutionary heritage and our unprecedented ability to shape and redefine our surroundings.
In my lab, we constantly ask, ‘What’s the utility of this pure science that we’re doing?
George Church’s approach to scientific inquiry, as reflected in the ethos of his lab, underscores the symbiotic relationship between foundational research and practical application. By persistently questioning the utility of their “pure science” endeavors, Church emphasizes the importance of advancing knowledge for its own sake and seeking tangible benefits and solutions for broader societal challenges. This perspective champions a holistic approach to research, where the pursuit of understanding is continually aligned with the potential for innovation and real-world impact, ensuring that science both elucidates the mysteries of the universe and enhances the human experience within it.
The rewards for biotechnology are tremendous – to solve disease, eliminate poverty, and age gracefully.
George Church’s perspective on biotechnology accentuates its profound potential to address some of humanity’s most pressing challenges. By framing biotechnology as a tool to “solve disease, eliminate poverty, and age gracefully,” Church encapsulates the holistic benefits that extend from individual health to broader socioeconomic betterment. His vision underscores that biotechnological advancements aren’t just about clinical or technical breakthroughs but about elevating the overall quality of human life. This viewpoint champions a future where science and technology work harmoniously to transcend our inherent biological limitations and create a more equitable and prosperous society for all.
It’s all too easy to dismiss the future. People confuse what’s impossible today with what’s impossible tomorrow.
George Church’s insight into the perception of the future underlines the human tendency to conflate current limitations with permanent impossibilities. By highlighting this cognitive pitfall, Church emphasizes the dynamic nature of progress, suggesting that what seems unattainable today might be within reach tomorrow. This perspective encourages open-mindedness, adaptability, and a refusal to be constrained by present challenges. Church’s wisdom serves as a reminder that the trajectory of innovation is often unpredictable, and dismissing the potential of the future based on today’s paradigm can hinder the progress that could redefine the boundaries of possibility.
Things that many think are a million years away, or never, are actually four years away.
George Church’s observation of the rapid pace of innovation challenges conventional notions of temporal expectations. By contrasting the perceived timeline of “a million years” with the “four years” reality, Church underscores the exponential progress in fields like biotechnology, where advancements can drastically outpace even optimistic predictions. His statement serves as a call to recalibrate our anticipations, suggesting that we must remain open to the possibility that transformative breakthroughs might be closer on the horizon than we think. Church’s insight emphasizes the thrilling unpredictability of scientific endeavors and cautions against underestimating the speed at which change can manifest.
I don’t actually believe there’s any such thing as privacy.
George Church’s provocative stance on privacy challenges traditional notions and underscores the complexities of living in an increasingly interconnected and digitally transparent age. By asserting the nonexistence of true solitude, Church points to the ubiquity of shared information, surveillance technologies, and the ease with which personal data can be accessed or disseminated. This perspective prompts critical reflection on how we understand and navigate privacy in contemporary society. Rather than clinging to perhaps outdated conceptions of seclusion, Church’s statement suggests the need for adaptive strategies, emphasizing informed data management and fostering awareness of the intricate webs of information we’re enmeshed in.
I’m pathologically calm.
George Church’s self-description as “pathologically calm” highlights the value of equanimity, especially in fields rife with uncertainty and complexity like genetic research. This unflappable demeanor, conveyed through the term “pathological,” suggests an extreme level of serenity, enabling Church to face challenges, setbacks, and breakthroughs with a consistent and clear-headed approach. Such calmness, especially in science and innovation, can be instrumental in ensuring objective analysis, fostering resilience in the face of failure, and maintaining a steady course amid the inevitable highs and lows of discovery. Church’s temperament is a testament to the importance of emotional stability in pursuing knowledge and innovation.
Letting the tundra melt is the equivalent of burning all of the forests in the world and their roots two and a half times over.
George Church’s analogy between the melting tundra and the burning of global forests vividly conveys the profound environmental implications of permafrost thawing due to climate change. By likening the release of carbon and methane from melting tundra to the destruction of forests, Church underscores the massive scale and potentially catastrophic consequences of this often overlooked ecological issue. His comparison serves as a potent call to action, emphasizing the urgency of addressing deforestation and the more insidious and less visible threat posed by melting permafrost. Through this vivid parallel, Church highlights the interconnectedness of our planet’s ecosystems and the compounding dangers of destabilizing any one component.
We might want to figure out the positive effects of autism – mild cases.
George Church’s perspective on exploring the potential positive effects of mild autism showcases an enlightened approach to neurodiversity, suggesting that conditions often perceived in purely pathological terms might also possess advantageous aspects. By encouraging a deeper understanding of mild autism beyond its challenges, Church promotes a broader appreciation for the unique cognitive profiles and strengths accompanying such conditions, like heightened focus, pattern recognition, or specialized skills. This viewpoint shifts the narrative from a deficit-centric model to one that recognizes and celebrates the potential gifts embedded within neurodiverse populations, fostering a more holistic and nuanced understanding of human cognition.
Your genetics is not your destiny.
George Church’s assertion that “your genetics is not your destiny” encapsulates the dynamic interplay between our inherited genetic code and the myriad factors that shape our lives, from the environment to personal choices. While genetics provides a foundational blueprint for our biological selves, Church’s statement emphasizes that it doesn’t rigidly predetermine our futures. This perspective empowers individuals to influence and navigate their health, behaviors, and overall life trajectories despite inherent genetic predispositions. By highlighting the malleability of our destinies, Church underscores the significance of proactive health decisions, environmental factors, and the rapidly advancing potential of genetic interventions in shaping individual outcomes.












