I’ve been asking a series of increasingly difficult questions to be answered about controlling body weight. What determines the body weight setpoint? It is known that sustained high insulin raises the set point. That is easily observed because people who are injecting insulin gain weight. They are injecting insulin to lower blood sugar, glucose, but the long-term effect of those injections is the body’s growing resistance to the insulin, which requires higher and higher doses of insulin to maintain a normal glucose level.

Does sustained low insulin in the blood lower the set point for the body? The existing setpoint is generally measured by the level of glucose in the early morning before eating. An average glucose level of a normal lean person is about 12 uU/mL and an obese diabetic about 18. (The Obesity Code by Jason Fung p. 77.) For a nondiabetic, the blood sugars are stable whether you eat six times a day or six times a month. (p. 121.) How can an individual set their glucose level to that of a lean person?

It has been observed that fasting for a few days will lower the glucose level of an obese person temporarily, but does it lower their set point? Probably not from a single several days’ fast, but from a year-long daily eighteen-hour fast there will probably be a significant weight loss and a lowering of the setpoint.

Does a year-long easy daily fasting stabilize at the lower setpoint? My personal experience is that it seems to have done that because I don’t have any sudden increase in weight when I basically ignore my current diet. I just eat normally by my new habitual eating routine now without any snacking between meals and that includes between my last meal at six pm and my first one at noon.

A year-long daily intermittent fast stabilizes at a lower body weight setpoint.