There are approximately 10,000,000,000,000,000,000,001 stars in the Universe, but only our planet, in the narrow Goldilocks Zone, is known to have life. Of the 13,800,000,001 years of the Universe today is only 1/365th of that single last year; and your conscious now is only the last one second of the 435,400,000,000,000,001 seconds. Of the tiny speck we call Earth, you occupy only that last 1 square meter of 510,072,000,000,001 square meters. When we are measured compared to the grandeur of space and time, you and I are small, and yet we are conscious at this moment and potentially conscious of our being conscious if we choose to direct our attention to that option. There are possibly other conscious beings, but we have no experience of that, and may never have because they are so far away.
Those many zeros listed above can be strung together, but there can be many more added on before we come to us as individuals When we consider DNA possibilities, there are many more zeros, and many more when we consider environmental possibilities that could have happened to us by random actions. That material existence mentioned so far is outside of our consciousness and free will, it is beyond our choosing or affecting, and yet all of that vanishes into insignificance compared to what is available to us with our choices.
Matter does what it does, and much of that is random on a fine scale, but on the grander scale it is quite fixed. Flipping a coin is fifty-fifty heads or tails when it is flipped once, but when it is flipped with a hundred zeros after the trial number, macroscopic things become fixed. In the real world, large enough for us to see and feel, these types of things become fixed so far as our relationship to them is concerned.
It is within our options to live fully and have a powerful effect on some local things, but we should be fully aware of what we will not be affecting, and that is almost everything. The vast stretches of time and space that came before us we can not affect in the smallest imaginable way, and the even greater time and space of the future are also totally beyond our influence; and because we can have no influence we have no responsibility and having no responsibility we need have no concern and no guilt or shame for the way those things behave. All we need to do is to be aware of their fixed nature and respond to them appropriately.
Once we accept our place in the Universe our lives become more meaningful because we then strive to help our fellow creatures to live their lives more fully.